Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice

Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice

Alkaline sphingomyelinase (alk-SMase) hydrolyses sphingomyelin (SM) to ceramide in the gut. To evaluate the physiological importance of the enzyme, we generated alk-SMase knockout (KO) mice by the Cre-recombinase-Locus of X-over P1(Cre-LoxP) system and studied SM digestion. Both wild-type (WT) and K...

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Bibliographic Details
Main Authors: Yao Zhang, Yajun Cheng, Gert H. Hansen, Lise-Lotte Niels-Christiansen, Frank Koentgen, Lena Ohlsson, Åke Nilsson, Rui-Dong Duan
Format: Article
Language:English
Published: Elsevier 2011-04-01
Series:Journal of Lipid Research
Subjects:
alkaline phosphatase
NPP7
hypertrophy
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520409101

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http://www.sciencedirect.com/science/article/pii/S0022227520409101

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