RELATIONSHIP BETWEEN T CELL IMMUNITY PARAMETERS AND SMOOTH-CELL CARCINOMA ANTIGEN (SCCA) CONTENTS IN BLOOD SERUM FROM THE PATIENTS WITH LOCAL DISSEMINATED FORMS OF UTERINE CERVIX CANCER

• Main Authors: I. L. Baturina, I. Yu. Orner, O. S. Abramovskikh, L. F. Telesheva, A. V, Zharov, K. V. Nikushkina
• Format: Article
• Language: Russian
• Published: SPb RAACI 2014-07-01
• Series: Medicinskaâ Immunologiâ
• Subjects: scc; tcell immunity; cervical cancer
• Online Access: https://www.mimmun.ru/mimmun/article/view/209

Uterine cervical cancer is among the main items of modern oncology. Determination of SCCA levels in blood serum of women with locally disseminated forms of uterine cervical cancer has a great significance for estimation the extent of lesions, tumor progression patterns, as well as treatment monitoring. During our study, we have determined that, before starting a specific treatment, all the patients with locally disseminated forms of cervical cancer had high serum levels of SCCA, along with suppressed anti-tumor immunity.Interestingly, high SCCA levels in blood serum proved to correlate with a decrease in anti-tumor immunity factors in those patients who showed a negative dynamics of tumor progression within one year after the therapy was performed. Meanwhile, the patients with positive post-treatment dynamics exhibited a significant decrease of SCCA levels over a year after therapy, as compared with appropriate pre-treatment values, accompanied by increase in anti-tumor immunity markers in these cases.