LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia.

LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia.

Long-term exposure to elevated levels of manganese (Mn) causes manganism, a neurodegenerative disorder with Parkinson's disease (PD)-like symptoms. Increasing evidence suggests that leucine-rich repeat kinase 2 (LRRK2), which is highly expressed in microglia and macrophages, contributes to the...

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Bibliographic Details
Main Authors: Judong Kim, Edward Pajarillo, Asha Rizor, Deok-Soo Son, Jayden Lee, Michael Aschner, Eunsook Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0210248

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