Serologically defined variations in malaria endemicity in Pará state, Brazil.

Measurement of malaria endemicity is typically based on vector or parasite measures. A complementary approach is the detection of parasite specific IgG antibodies. We determined the antibody levels and seroconversion rates to both P. vivax and P. falciparum merozoite antigens in individuals living i...

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Main Authors: Maristela G Cunha, Eliane S Silva, Nuno Sepúlveda, Sheyla P T Costa, Tiago C Saboia, João F Guerreiro, Marinete M Póvoa, Patrick H Corran, Eleanor Riley, Chris J Drakeley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4242530?pdf=render
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spelling doaj-a6ad58be649d4efea9d0816aec420be92020-11-24T22:14:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11335710.1371/journal.pone.0113357Serologically defined variations in malaria endemicity in Pará state, Brazil.Maristela G CunhaEliane S SilvaNuno SepúlvedaSheyla P T CostaTiago C SaboiaJoão F GuerreiroMarinete M PóvoaPatrick H CorranEleanor RileyChris J DrakeleyMeasurement of malaria endemicity is typically based on vector or parasite measures. A complementary approach is the detection of parasite specific IgG antibodies. We determined the antibody levels and seroconversion rates to both P. vivax and P. falciparum merozoite antigens in individuals living in areas of varying P. vivax endemicity in Pará state, Brazilian Amazon region.The prevalence of antibodies to recombinant antigens from P. vivax and P. falciparum was determined in 1,330 individuals. Cross sectional surveys were conducted in the north of Brazil in Anajás, Belém, Goianésia do Pará, Jacareacanga, Itaituba, Trairão, all in the Pará state, and Sucuriju, a free-malaria site in the neighboring state Amapá. Seroprevalence to any P. vivax antigens (MSP1 or AMA-1) was 52.5%, whereas 24.7% of the individuals were seropositive to any P. falciparum antigens (MSP1 or AMA-1). For P. vivax antigens, the seroconversion rates (SCR) ranged from 0.005 (Sucuriju) to 0.201 (Goianésia do Pará), and are strongly correlated to the corresponding Annual Parasite Index (API). We detected two sites with distinct characteristics: Goianésia do Pará where seroprevalence curve does not change with age, and Sucuriju where seroprevalence curve is better described by a model with two SCRs compatible with a decrease in force of infection occurred 14 years ago (from 0.069 to 0.005). For P. falciparum antigens, current SCR estimates varied from 0.002 (Belém) to 0.018 (Goianésia do Pará). We also detected a putative decrease in disease transmission occurred ∼29 years ago in Anajás, Goianésia do Pará, Itaituba, Jacareacanga, and Trairão.We observed heterogeneity of serological indices across study sites with different endemicity levels and temporal changes in the force of infection in some of the sites. Our study provides further evidence that serology can be used to measure and monitor transmission of both major species of malaria parasite.http://europepmc.org/articles/PMC4242530?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Maristela G Cunha
Eliane S Silva
Nuno Sepúlveda
Sheyla P T Costa
Tiago C Saboia
João F Guerreiro
Marinete M Póvoa
Patrick H Corran
Eleanor Riley
Chris J Drakeley
spellingShingle Maristela G Cunha
Eliane S Silva
Nuno Sepúlveda
Sheyla P T Costa
Tiago C Saboia
João F Guerreiro
Marinete M Póvoa
Patrick H Corran
Eleanor Riley
Chris J Drakeley
Serologically defined variations in malaria endemicity in Pará state, Brazil.
PLoS ONE
author_facet Maristela G Cunha
Eliane S Silva
Nuno Sepúlveda
Sheyla P T Costa
Tiago C Saboia
João F Guerreiro
Marinete M Póvoa
Patrick H Corran
Eleanor Riley
Chris J Drakeley
author_sort Maristela G Cunha
title Serologically defined variations in malaria endemicity in Pará state, Brazil.
title_short Serologically defined variations in malaria endemicity in Pará state, Brazil.
title_full Serologically defined variations in malaria endemicity in Pará state, Brazil.
title_fullStr Serologically defined variations in malaria endemicity in Pará state, Brazil.
title_full_unstemmed Serologically defined variations in malaria endemicity in Pará state, Brazil.
title_sort serologically defined variations in malaria endemicity in pará state, brazil.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description Measurement of malaria endemicity is typically based on vector or parasite measures. A complementary approach is the detection of parasite specific IgG antibodies. We determined the antibody levels and seroconversion rates to both P. vivax and P. falciparum merozoite antigens in individuals living in areas of varying P. vivax endemicity in Pará state, Brazilian Amazon region.The prevalence of antibodies to recombinant antigens from P. vivax and P. falciparum was determined in 1,330 individuals. Cross sectional surveys were conducted in the north of Brazil in Anajás, Belém, Goianésia do Pará, Jacareacanga, Itaituba, Trairão, all in the Pará state, and Sucuriju, a free-malaria site in the neighboring state Amapá. Seroprevalence to any P. vivax antigens (MSP1 or AMA-1) was 52.5%, whereas 24.7% of the individuals were seropositive to any P. falciparum antigens (MSP1 or AMA-1). For P. vivax antigens, the seroconversion rates (SCR) ranged from 0.005 (Sucuriju) to 0.201 (Goianésia do Pará), and are strongly correlated to the corresponding Annual Parasite Index (API). We detected two sites with distinct characteristics: Goianésia do Pará where seroprevalence curve does not change with age, and Sucuriju where seroprevalence curve is better described by a model with two SCRs compatible with a decrease in force of infection occurred 14 years ago (from 0.069 to 0.005). For P. falciparum antigens, current SCR estimates varied from 0.002 (Belém) to 0.018 (Goianésia do Pará). We also detected a putative decrease in disease transmission occurred ∼29 years ago in Anajás, Goianésia do Pará, Itaituba, Jacareacanga, and Trairão.We observed heterogeneity of serological indices across study sites with different endemicity levels and temporal changes in the force of infection in some of the sites. Our study provides further evidence that serology can be used to measure and monitor transmission of both major species of malaria parasite.
url http://europepmc.org/articles/PMC4242530?pdf=render
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