Mesoporous Silica Nanoparticles Modified inside and out for ON:OFF pH-Modulated Cargo Release

Mesoporous Silica Nanoparticles Modified inside and out for ON:OFF pH-Modulated Cargo Release

Highly efficient pH-modulated cargo release was achieved with a new hybrid nanocarrier composed of a mesoporous silica core with functionalized pores and a grafted pH-responsive crosslinked polymer shell of 2-(diisopropylamino)ethyl methacrylate (pKa ≈ 6.5). The retention/release performance of the...

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Bibliographic Details
Main Authors: José L. M. Gonçalves, Ana Beatriz C. Lopes, Carlos Baleizão, José Paulo S. Farinha
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
core-shell hybrid mesoporous silica nanoparticles
pH-responsive polymers
modulated cargo release
pore functionalization
RAFT
Online Access:https://www.mdpi.com/1999-4923/13/5/716

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