IPEC-J2 rMdr1a and a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

IPEC-J2 rMdr1a and a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

The efflux pump P-glycoprotein (P-gp) affects drug distribution after absorption in humans and animals. P-gp is encoded by the multidrug resistance gene (MDR1) gene in humans, while rodents (the most common preclinical animal model) express the two isoforms Mdr1a and Mdr1b. Differences in substrate...

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Bibliographic Details
Main Authors: Lasse Saaby, Josefine Trasborg, Mikkel A. Rasmussen, Bjørn Holst, Birger Brodin
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceutics
Subjects:
P-glycoprotein (ABCB1)
P-gp substrates
efflux transport
in vitro model
species differences
drug delivery
Online Access:https://www.mdpi.com/1999-4923/12/7/673

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