Five Predictors Affecting the Prognosis of Patients with Severe Odontogenic Infections

• Main Authors: Nathalie Pham Dang, Candice Delbet-Dupas, Aurélien Mulliez, Laurent Devoize, Radhouane Dallel, Isabelle Barthélémy
• Format: Article
• Language: English
• Published: MDPI AG 2020-11-01
• Series: International Journal of Environmental Research and Public Health
• Subjects: severe odontogenic infection; cellulitis; allergy; predictor
• Online Access: https://www.mdpi.com/1660-4601/17/23/8917

<i>Background</i>: Dental cellulitis management is no longer a simple procedure, as more and more patients are needing long-time hospitalization, several surgeries and intensive care follow-up. This prospective study seeks to highlight criteria that can split patients with severe odontogenic infection into two groups: those with simple evolution and those for whom complex management is necessary. <i>Methods</i>: In this observational study, all patients considered with a severe odontogenic infection (which necessitated hospital admission, intravenous antibiotics and general anaesthesia) were enrolled between January 2004 and December 2014 from Clermont-Ferrand University Hospital (France). They were split into two groups: those who needed one surgical intervention with tooth extraction and collection drainage combined with probabilistic antibiotic to treat infection and those who need several surgeries, intensive care unit follow-up or tracheotomy to achieve healing. <i>Results</i>: 653 patients were included, of which 611 (94%) had one surgery, 42 (6%) had more than one surgery before healing. Penicillin allergy (<i>p</i> < 0.001), psychiatric disorders (<i>p</i> = 0.005), oropharyngeal oedema (<i>p </i>= 0.008), floor oedema (<i>p </i>= 0.004), fever (<i>p </i>= 0.04) and trismus (<i>p </i>= 0.018) on admission were the most relevant predictors of complex evolution. A conditional inference tree (CTREE) illustrated the association of prognostic factors and the need of multiple surgery. <i>Conclusion</i><i>s</i>: Besides clinical symptoms of severity, complications of severe odontogenic infection are predicted by measurables and objectives criteria as penicillin allergy, mandibular molar, C-reactive protein level, psychiatric disorders and alcohol abuse. Their specific association potentialize the risks. IRB number: CE-CIC-GREN-12-08.