Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis

Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis

The blood-brain barrier (BBB) is formed by the endothelial cells lining cerebral microvessels, but how blood-borne signaling molecules influence permeability is incompletely understood. We here examined how the apolipoprotein M (apoM)-bound sphingosine 1–phosphate (S1P) signaling pathway affects the...

Full description

Bibliographic Details
Main Authors: Mette Mathiesen Janiurek, Rana Soylu-Kucharz, Christina Christoffersen, Krzysztof Kucharz, Martin Lauritzen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
mouse
C57B6/J
ApoM-/-
Online Access:https://elifesciences.org/articles/49405

Similar Items

Similar Items