CircIBTK inhibits DNA demethylation and activation of AKT signaling pathway via miR-29b in peripheral blood mononuclear cells in systemic lupus erythematosus

CircIBTK inhibits DNA demethylation and activation of AKT signaling pathway via miR-29b in peripheral blood mononuclear cells in systemic lupus erythematosus

Abstract Background Systemic lupus erythematosus (SLE) is a chronic and incurable autoimmune disease involving the dysfunction of lymphocytes. Circular RNAs (circRNAs) are noncoding RNAs (ncRNAs) with a covalently closed loop structure, with abnormal expression in various human diseases may particip...

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Bibliographic Details
Main Authors: Xin Wang, Chengzhong Zhang, Zhouwei Wu, Yue Chen, Weimin Shi
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Arthritis Research & Therapy
Subjects:
Systemic lupus erythematosus
Circular RNAs
miR-29b
DNA methylation
AKT signaling
Online Access:http://link.springer.com/article/10.1186/s13075-018-1618-8

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