Tumor-Secreted GRP78 Promotes the Establishment of a Pre-metastatic Niche in the Liver Microenvironment

Tumor-Secreted GRP78 Promotes the Establishment of a Pre-metastatic Niche in the Liver Microenvironment

The liver is an immunologically tolerant organ and a common site of distant metastasis for various cancers. The expression levels of glucose-regulated protein 78 (GRP78) have been associated with tumor malignancy. Secretory GRP78 (sGRP78) released from tumor cells contributes to the establishment of...

Full description

Bibliographic Details
Main Authors: Lu Chen, Hao Zheng, Xiang Yu, Lei Liu, Heli Li, Huifen Zhu, Zhihong Zhang, Ping Lei, Guanxin Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
tumor-secreted GRP78
liver pro-metastatic niche
dendritic cells
macrophages
natural killers
immunomodulation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.584458/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.584458/full

Similar Items