A Strategy to Delay the Development of Cisplatin Resistance by Maintaining a Certain Amount of Cisplatin-Sensitive Cells

Abstract Cisplatin (ddp), which is commonly employed in the treatment of many advanced cancers, often results in initial therapeutic success; however, rapid progression of ddp-resistant cells remains the main reason for treatment failure. Facd with such a problem, we investigated the fitness differe...

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Bibliographic Details
Main Authors: Guihua Duan, Qianyuan Tang, Hongli Yan, Lijuan Xie, Yun Wang, Xi Emily Zheng, Yuzheng Zhuge, Shanshan Shen, Bin Zhang, Xiaoqi Zhang, Jun Wang, Wei Wang, Xiaoping Zou
Format: Article
Language:English
Published: Nature Publishing Group 2017-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-00422-2