Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology
Pure total flavonoids from Citrus (PTFC) effectively reduce the symptoms of non-alcoholic fatty liver disease (NAFLD). Our previous microarray analysis uncovered the alterations of important signaling pathways in the treatment of NAFLD with PTFC. However, the underlying core genes that might be targ...
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Frontiers Media S.A.
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.00582/full |
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doaj-a6885be514844aa98667dbbc6d6bf7962020-11-25T01:09:10ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-06-011010.3389/fphar.2019.00582449600Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network PharmacologyWei Hong0Wei Hong1Songsong Li2Songsong Li3Liyan Wu4Liyan Wu5Beihui He6Beihui He7Jianping Jiang8Jianping Jiang9Zhiyun Chen10Zhiyun Chen11The Second Central Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province, Hangzhou, ChinaThe Second Central Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province, Hangzhou, ChinaThe Second Central Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province, Hangzhou, ChinaThe Second Central Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province, Hangzhou, ChinaThe Second Central Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province, Hangzhou, ChinaThe Second Central Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province, Hangzhou, ChinaPure total flavonoids from Citrus (PTFC) effectively reduce the symptoms of non-alcoholic fatty liver disease (NAFLD). Our previous microarray analysis uncovered the alterations of important signaling pathways in the treatment of NAFLD with PTFC. However, the underlying core genes that might be targeted by PTFC, which play important roles in the progression of NALFD are yet to be identified. In this study, we predicted the vascular endothelial growth factor-C (VEGF-C) as potential key molecular target of PTFC against NAFLD via network pharmacology analysis. The network pharmacology approach presented here provided important clues for understanding the mechanisms of PTFC treatment in the development of NAFLD.https://www.frontiersin.org/article/10.3389/fphar.2019.00582/fullpure total flavonoids from citrusnon-alcoholic fatty liver diseasevascular endothelial growth factor-Cnetwork pharmacologynon-alcoholic steatohepatitis |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Wei Hong Wei Hong Songsong Li Songsong Li Liyan Wu Liyan Wu Beihui He Beihui He Jianping Jiang Jianping Jiang Zhiyun Chen Zhiyun Chen |
| spellingShingle |
Wei Hong Wei Hong Songsong Li Songsong Li Liyan Wu Liyan Wu Beihui He Beihui He Jianping Jiang Jianping Jiang Zhiyun Chen Zhiyun Chen Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology Frontiers in Pharmacology pure total flavonoids from citrus non-alcoholic fatty liver disease vascular endothelial growth factor-C network pharmacology non-alcoholic steatohepatitis |
| author_facet |
Wei Hong Wei Hong Songsong Li Songsong Li Liyan Wu Liyan Wu Beihui He Beihui He Jianping Jiang Jianping Jiang Zhiyun Chen Zhiyun Chen |
| author_sort |
Wei Hong |
| title |
Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology |
| title_short |
Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology |
| title_full |
Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology |
| title_fullStr |
Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology |
| title_full_unstemmed |
Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology |
| title_sort |
prediction of vegf-c as a key target of pure total flavonoids from citrus against nafld in mice via network pharmacology |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Pharmacology |
| issn |
1663-9812 |
| publishDate |
2019-06-01 |
| description |
Pure total flavonoids from Citrus (PTFC) effectively reduce the symptoms of non-alcoholic fatty liver disease (NAFLD). Our previous microarray analysis uncovered the alterations of important signaling pathways in the treatment of NAFLD with PTFC. However, the underlying core genes that might be targeted by PTFC, which play important roles in the progression of NALFD are yet to be identified. In this study, we predicted the vascular endothelial growth factor-C (VEGF-C) as potential key molecular target of PTFC against NAFLD via network pharmacology analysis. The network pharmacology approach presented here provided important clues for understanding the mechanisms of PTFC treatment in the development of NAFLD. |
| topic |
pure total flavonoids from citrus non-alcoholic fatty liver disease vascular endothelial growth factor-C network pharmacology non-alcoholic steatohepatitis |
| url |
https://www.frontiersin.org/article/10.3389/fphar.2019.00582/full |
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