A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds
Bile acids (BAs) are amphiphilic compounds and of recently have demonstrated wide range of formulation stabilizing effects. A recent study showed that primary un-metabolised bile acids (PUBAs) have β-cell protective effects, and synergistic antidiabetic effects when combined with antioxidant and ant...
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Elsevier
2020-02-01
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| Series: | Saudi Pharmaceutical Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016419301689 |
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doaj-a684e820a1b14485bae8beeedf0a0db82020-11-24T23:59:30ZengElsevierSaudi Pharmaceutical Journal1319-01642020-02-01282165171A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compoundsArmin Mooranian0Nassim Zamani1Momir Mikov2Svetlana Goločorbin-Kon3Goran Stojanovic4Frank Arfuso5Bozica Kovacevic6Hani Al-Salami7Biotechnology and Drug Development Research Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, AustraliaBiotechnology and Drug Development Research Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, AustraliaDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Novi Sad, SerbiaDepartment of Pharmacy, University of Novi Sad, Novi Sad, SerbiaFaculty of Technical Sciences, University of Novi Sad, Novi Sad, SerbiaStem Cell and Cancer Biology Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, AustraliaBiotechnology and Drug Development Research Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, AustraliaBiotechnology and Drug Development Research Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia; Corresponding author at: Senior Lecturer of Pharmaceutics Founder of Biotechnology and Drug Development Research Laboratory School of Pharmacy and Biomedical Sciences Curtin Health Innovation Research Institute (CHIRI) Curtin University, Perth, WA, Australia.Bile acids (BAs) are amphiphilic compounds and of recently have demonstrated wide range of formulation stabilizing effects. A recent study showed that primary un-metabolised bile acids (PUBAs) have β-cell protective effects, and synergistic antidiabetic effects when combined with antioxidant and anti-inflammatory drugs, such as probucol (PB). Thus, this study aimed to design and test microcapsules containing a PUBA incorporated with PB and an alginate-Eudragit matrix.Six types of microcapsules were developed without (control) or with (test) PUBA, and tested for internal and external features and β-cell protective effects.The incorporation of PB-alginate-Eudragit with PUBA produced stable microcapsules but did not exert consistent positive effects on cell viability in the hyperglycaemic state, which suggests that PUBA in alginate-Eudragit matrices did not exhibit synergistic effects with PB nor exerted antidiabetic effects. Keywords: Probucol, Microencapsulation, Eudragit, Alginate, Oral delivery, Diabetes mellitushttp://www.sciencedirect.com/science/article/pii/S1319016419301689 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Armin Mooranian Nassim Zamani Momir Mikov Svetlana Goločorbin-Kon Goran Stojanovic Frank Arfuso Bozica Kovacevic Hani Al-Salami |
| spellingShingle |
Armin Mooranian Nassim Zamani Momir Mikov Svetlana Goločorbin-Kon Goran Stojanovic Frank Arfuso Bozica Kovacevic Hani Al-Salami A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds Saudi Pharmaceutical Journal |
| author_facet |
Armin Mooranian Nassim Zamani Momir Mikov Svetlana Goločorbin-Kon Goran Stojanovic Frank Arfuso Bozica Kovacevic Hani Al-Salami |
| author_sort |
Armin Mooranian |
| title |
A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds |
| title_short |
A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds |
| title_full |
A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds |
| title_fullStr |
A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds |
| title_full_unstemmed |
A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds |
| title_sort |
second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by eudragit-alginate complex with antioxidant compounds |
| publisher |
Elsevier |
| series |
Saudi Pharmaceutical Journal |
| issn |
1319-0164 |
| publishDate |
2020-02-01 |
| description |
Bile acids (BAs) are amphiphilic compounds and of recently have demonstrated wide range of formulation stabilizing effects. A recent study showed that primary un-metabolised bile acids (PUBAs) have β-cell protective effects, and synergistic antidiabetic effects when combined with antioxidant and anti-inflammatory drugs, such as probucol (PB). Thus, this study aimed to design and test microcapsules containing a PUBA incorporated with PB and an alginate-Eudragit matrix.Six types of microcapsules were developed without (control) or with (test) PUBA, and tested for internal and external features and β-cell protective effects.The incorporation of PB-alginate-Eudragit with PUBA produced stable microcapsules but did not exert consistent positive effects on cell viability in the hyperglycaemic state, which suggests that PUBA in alginate-Eudragit matrices did not exhibit synergistic effects with PB nor exerted antidiabetic effects. Keywords: Probucol, Microencapsulation, Eudragit, Alginate, Oral delivery, Diabetes mellitus |
| url |
http://www.sciencedirect.com/science/article/pii/S1319016419301689 |
| work_keys_str_mv |
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