Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function

eNOS expression is dynamically regulated both transcriptionally and post-transcriptionally by various stimuli. Here the authors identify an enhancer-associated lncRNA (LEENE) that is co-regulated with, and enhances eNOS expression.

Bibliographic Details
Main Authors:	Yifei Miao, Nassim E. Ajami, Tse-Shun Huang, Feng-Mao Lin, Chih-Hong Lou, Yun-Ting Wang, Shuai Li, Jian Kang, Hannah Munkacsi, Mano R. Maurya, Shakti Gupta, Shu Chien, Shankar Subramaniam, Zhen Chen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02113-y

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spelling	doaj-a67095a0978f4a1bbc2ae67affad39702021-05-11T10:32:13ZengNature Publishing GroupNature Communications2041-17232018-01-019111310.1038/s41467-017-02113-yEnhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial functionYifei Miao0Nassim E. Ajami1Tse-Shun Huang2Feng-Mao Lin3Chih-Hong Lou4Yun-Ting Wang5Shuai Li6Jian Kang7Hannah Munkacsi8Mano R. Maurya9Shakti Gupta10Shu Chien11Shankar Subramaniam12Zhen Chen13Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of HopeBioinformatics and Systems Biology Graduate Program, University of California at San DiegoDepartment of Bioengineering and Institute of Engineering in Medicine, University of California at San DiegoDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of HopeGenome Editing Core, Beckman Research Institute, City of HopeDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of HopeDepartment of Medicine, University of California at San DiegoDepartment of Medicine, University of California at San DiegoGenome Editing Core, Beckman Research Institute, City of HopeDepartment of Bioengineering and Institute of Engineering in Medicine, University of California at San DiegoDepartment of Bioengineering and Institute of Engineering in Medicine, University of California at San DiegoDepartment of Bioengineering and Institute of Engineering in Medicine, University of California at San DiegoDepartment of Bioengineering and Institute of Engineering in Medicine, University of California at San DiegoDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of HopeeNOS expression is dynamically regulated both transcriptionally and post-transcriptionally by various stimuli. Here the authors identify an enhancer-associated lncRNA (LEENE) that is co-regulated with, and enhances eNOS expression.https://doi.org/10.1038/s41467-017-02113-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yifei Miao Nassim E. Ajami Tse-Shun Huang Feng-Mao Lin Chih-Hong Lou Yun-Ting Wang Shuai Li Jian Kang Hannah Munkacsi Mano R. Maurya Shakti Gupta Shu Chien Shankar Subramaniam Zhen Chen
spellingShingle	Yifei Miao Nassim E. Ajami Tse-Shun Huang Feng-Mao Lin Chih-Hong Lou Yun-Ting Wang Shuai Li Jian Kang Hannah Munkacsi Mano R. Maurya Shakti Gupta Shu Chien Shankar Subramaniam Zhen Chen Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function Nature Communications
author_facet	Yifei Miao Nassim E. Ajami Tse-Shun Huang Feng-Mao Lin Chih-Hong Lou Yun-Ting Wang Shuai Li Jian Kang Hannah Munkacsi Mano R. Maurya Shakti Gupta Shu Chien Shankar Subramaniam Zhen Chen
author_sort	Yifei Miao
title	Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function
title_short	Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function
title_full	Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function
title_fullStr	Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function
title_full_unstemmed	Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function
title_sort	enhancer-associated long non-coding rna leene regulates endothelial nitric oxide synthase and endothelial function
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	eNOS expression is dynamically regulated both transcriptionally and post-transcriptionally by various stimuli. Here the authors identify an enhancer-associated lncRNA (LEENE) that is co-regulated with, and enhances eNOS expression.
url	https://doi.org/10.1038/s41467-017-02113-y
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Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function

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