Changes of inflammatory factors and adipokines in patients with diabetic osteoporosis

• Main Authors: Ning-Xu Li, Yan Tu, Xiao-Xia Liu, Ying Shen, Li-Hua Zhang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-03-01
• Series: Journal of Hainan Medical University
• Subjects: Diabetes; Osteoporosis; Inflammatory factors; Adipokines
• Online Access: http://www.jhmuweb.net/PDF/201605/7.pdf
• ISSN: 1007-1237; 1007-1237

Objective: This study aimed to investigate the changes of inflammatory factors and adipokines in patients with diabetic osteoporosis. Methods: A total of 142 type 2 diabetic patients were divided into osteoporosis group (OP, n=78) and non-osteoporosis group (NOP, n=64) according to the conditions of bone density. Then levels of blood lipid, inflammatory factors and adipokines were detected and compared. Results: As for blood lipids, the levels of low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were not significantly different between the two groups (P>0.05), while the levels of total cholesterol (TC) and triglyceride (TG) in the OP group were significantly higher than those in the NOP group (P<0.05); referring to inflammatory factors, the levels of monocyte chemoattractant protein-1 (MCP-1), hyper-sensitive C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) in the OP group were significantly increased compared with the NOP group (P<0.05); speaking to adipokines, the levels of visceral adipose tissue-derived serine protease inhibitor (vaspin) and adiponectin rose obviously and the level of visfatin declined apparently in the OP group compared with the NOP group (P<0.05). Conclusions: The alterations of the levels of inflammatory factors and adipokines might increase the risk of osteoporosis in patients with type 2 diabetes mellitus.