Cost effectiveness of pharmacogenetic-guided clozapine administration based on risk of HLA variants in Japan and the UK

Cost effectiveness of pharmacogenetic-guided clozapine administration based on risk of HLA variants in Japan and the UK

Abstract Pharmacogenetics/pharmacogenomics have enabled the detection of risk of human leukocyte antigen (HLA) variants for clozapine-induced agranulocytosis/granulocytopenia (CIAG). To apply this evidence to the clinical setting, we compared the cost-effectiveness of the proposed “HLA-guided treatm...

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Main Authors: kohei Ninomiya, Takeo Saito, Tomo Okochi, Satoru Taniguchi, Ayu Shimasaki, Rei Aoki, Takeo Hata, Taisei Mushiroda, Tetsufumi Kanazawa, Masashi Ikeda, Nakao Iwata
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01487-4

Internet

https://doi.org/10.1038/s41398-021-01487-4

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