Concomitant attenuation of HMGCR expression and activity enhances the growth inhibitory effect of atorvastatin on TGF-β-treated epithelial cancer cells

Concomitant attenuation of HMGCR expression and activity enhances the growth inhibitory effect of atorvastatin on TGF-β-treated epithelial cancer cells

Abstract Epithelial-mesenchymal transition (EMT) in primary tumor cells is a key prerequisite for metastasis initiation. Statins, cholesterol-lowering drugs, can delay metastasis formation in vivo and attenuate the growth and proliferation of tumor cells in vitro. The latter effect is stronger in tu...

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Bibliographic Details
Main Authors: Katsuhiko Warita, Takuro Ishikawa, Akihiro Sugiura, Jiro Tashiro, Hiroaki Shimakura, Yoshinao Z. Hosaka, Ken-ichi Ohta, Tomoko Warita, Zoltán N. Oltvai
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-91928-3

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