Network biology discovers pathogen contact points in host protein-protein interactomes
Nodes with high centrality in protein–protein interaction (PPI) networks are known to be essential in some organisms. Here, the authors in contrast find that in the interactome of A. thaliana central nodes are enriched in conditional and immune phenotypes and are preferred targets of pathogens.
Main Authors: | Hadia Ahmed, T. C. Howton, Yali Sun, Natascha Weinberger, Youssef Belkhadir, M. Shahid Mukhtar |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-06-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-04632-8 |
Similar Items
-
Discovering RNA-Protein Interactome by Using Chemical Context Profiling of the RNA-Protein Interface
by: Marc Parisien, et al.
Published: (2013-05-01) -
Intrinsically disordered proteins: controlled chaos or random walk
by: T.C. Howton, et al.
Published: (2016-02-01) -
Centrality in the host–pathogen interactome is associated with pathogen fitness during infection
by: Núria Crua Asensio, et al.
Published: (2017-01-01) -
Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses
by: Simonis Nicolas, et al.
Published: (2012-03-01) -
Interspecies RNA Interactome of Pathogen and Host in a Heritable Defensive Strategy
by: Marcela Legüe, et al.
Published: (2021-07-01)