Disrupting biological sensors of force promotes tissue regeneration in large organisms

Disrupting biological sensors of force promotes tissue regeneration in large organisms

Humans and other large mammals heal wounds by forming fibrotic scar tissue with diminished function. Here, the authors show that disrupting mechanotransduction through the focal adhesion kinase pathway in large animals accelerates healing, prevents fibrosis, and enhances skin regeneration.

Bibliographic Details
Main Authors: Kellen Chen, Sun Hyung Kwon, Dominic Henn, Britta A. Kuehlmann, Ruth Tevlin, Clark A. Bonham, Michelle Griffin, Artem A. Trotsyuk, Mimi R. Borrelli, Chikage Noishiki, Jagannath Padmanabhan, Janos A. Barrera, Zeshaan N. Maan, Teruyuki Dohi, Chyna J. Mays, Autumn H. Greco, Dharshan Sivaraj, John Q. Lin, Tobias Fehlmann, Alana M. Mermin-Bunnell, Smiti Mittal, Michael S. Hu, Alsu I. Zamaleeva, Andreas Keller, Jayakumar Rajadas, Michael T. Longaker, Michael Januszyk, Geoffrey C. Gurtner
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25410-z

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