Disrupting biological sensors of force promotes tissue regeneration in large organisms
Humans and other large mammals heal wounds by forming fibrotic scar tissue with diminished function. Here, the authors show that disrupting mechanotransduction through the focal adhesion kinase pathway in large animals accelerates healing, prevents fibrosis, and enhances skin regeneration.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25410-z |
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doaj-a6465911a4834ff9b70b7391526b7dc62021-09-12T11:45:53ZengNature Publishing GroupNature Communications2041-17232021-09-0112111510.1038/s41467-021-25410-zDisrupting biological sensors of force promotes tissue regeneration in large organismsKellen Chen0Sun Hyung Kwon1Dominic Henn2Britta A. Kuehlmann3Ruth Tevlin4Clark A. Bonham5Michelle Griffin6Artem A. Trotsyuk7Mimi R. Borrelli8Chikage Noishiki9Jagannath Padmanabhan10Janos A. Barrera11Zeshaan N. Maan12Teruyuki Dohi13Chyna J. Mays14Autumn H. Greco15Dharshan Sivaraj16John Q. Lin17Tobias Fehlmann18Alana M. Mermin-Bunnell19Smiti Mittal20Michael S. Hu21Alsu I. Zamaleeva22Andreas Keller23Jayakumar Rajadas24Michael T. Longaker25Michael Januszyk26Geoffrey C. Gurtner27Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineClinical Bioinformatics, Saarland UniversityDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineBiomaterials and Advanced Drug Delivery Laboratory, Stanford UniversityClinical Bioinformatics, Saarland UniversityBiomaterials and Advanced Drug Delivery Laboratory, Stanford UniversityDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineHumans and other large mammals heal wounds by forming fibrotic scar tissue with diminished function. Here, the authors show that disrupting mechanotransduction through the focal adhesion kinase pathway in large animals accelerates healing, prevents fibrosis, and enhances skin regeneration.https://doi.org/10.1038/s41467-021-25410-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kellen Chen Sun Hyung Kwon Dominic Henn Britta A. Kuehlmann Ruth Tevlin Clark A. Bonham Michelle Griffin Artem A. Trotsyuk Mimi R. Borrelli Chikage Noishiki Jagannath Padmanabhan Janos A. Barrera Zeshaan N. Maan Teruyuki Dohi Chyna J. Mays Autumn H. Greco Dharshan Sivaraj John Q. Lin Tobias Fehlmann Alana M. Mermin-Bunnell Smiti Mittal Michael S. Hu Alsu I. Zamaleeva Andreas Keller Jayakumar Rajadas Michael T. Longaker Michael Januszyk Geoffrey C. Gurtner |
| spellingShingle |
Kellen Chen Sun Hyung Kwon Dominic Henn Britta A. Kuehlmann Ruth Tevlin Clark A. Bonham Michelle Griffin Artem A. Trotsyuk Mimi R. Borrelli Chikage Noishiki Jagannath Padmanabhan Janos A. Barrera Zeshaan N. Maan Teruyuki Dohi Chyna J. Mays Autumn H. Greco Dharshan Sivaraj John Q. Lin Tobias Fehlmann Alana M. Mermin-Bunnell Smiti Mittal Michael S. Hu Alsu I. Zamaleeva Andreas Keller Jayakumar Rajadas Michael T. Longaker Michael Januszyk Geoffrey C. Gurtner Disrupting biological sensors of force promotes tissue regeneration in large organisms Nature Communications |
| author_facet |
Kellen Chen Sun Hyung Kwon Dominic Henn Britta A. Kuehlmann Ruth Tevlin Clark A. Bonham Michelle Griffin Artem A. Trotsyuk Mimi R. Borrelli Chikage Noishiki Jagannath Padmanabhan Janos A. Barrera Zeshaan N. Maan Teruyuki Dohi Chyna J. Mays Autumn H. Greco Dharshan Sivaraj John Q. Lin Tobias Fehlmann Alana M. Mermin-Bunnell Smiti Mittal Michael S. Hu Alsu I. Zamaleeva Andreas Keller Jayakumar Rajadas Michael T. Longaker Michael Januszyk Geoffrey C. Gurtner |
| author_sort |
Kellen Chen |
| title |
Disrupting biological sensors of force promotes tissue regeneration in large organisms |
| title_short |
Disrupting biological sensors of force promotes tissue regeneration in large organisms |
| title_full |
Disrupting biological sensors of force promotes tissue regeneration in large organisms |
| title_fullStr |
Disrupting biological sensors of force promotes tissue regeneration in large organisms |
| title_full_unstemmed |
Disrupting biological sensors of force promotes tissue regeneration in large organisms |
| title_sort |
disrupting biological sensors of force promotes tissue regeneration in large organisms |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-09-01 |
| description |
Humans and other large mammals heal wounds by forming fibrotic scar tissue with diminished function. Here, the authors show that disrupting mechanotransduction through the focal adhesion kinase pathway in large animals accelerates healing, prevents fibrosis, and enhances skin regeneration. |
| url |
https://doi.org/10.1038/s41467-021-25410-z |
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