| Summary: | <p>The present study was conducted to investigate total phenolic content, antioxidant and antibacterial activity of four <em>Senecio</em> L. (Asteraceae). The <em>in vitro</em> antioxidant activities of extracts were evaluated with different antioxidant testing systems. Their antioxidant activities were assessed by phosphomolybdenum reduction, DPPH and β-carotene bleaching assay. The extracts exhibited strong antioxidant activity and high scavenging activities against DPPH free radicals. While the extracts exhibited weak to moderate β-carotene bleaching activity. The antimicrobial activity of <em>Senecio </em>extracts was tested against 15 microorganisms using agar diffusion and broth microdilution assays. The extracts were found to be weak to moderate effective against 8 out of the 15 microorganisms tested with minimal inhibitory concentration (MIC) values ranging from 1.5 to 12.5 mg/ml. In conclusion, it can be concluded that <em>Senecio </em>extracts may be considered as natural sources in many industry such as food and pharmacy.</p>
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