The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca2+-permeable cation channel essential for immunocyte activation, insulin secretion, and postischemic cell death. TRPM2 is activated by ADP ribose (ADPR) binding to its C-terminal cytosolic NUDT9-homology (NUDT9H) domain, homologous to the solu...

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Bibliographic Details
Main Authors: Iordan Iordanov, Csaba Mihályi, Balázs Tóth, László Csanády
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
chanzyme
NUDT9H domain
chimera
ADPR
TRPM2
Online Access:https://elifesciences.org/articles/17600

Internet

https://elifesciences.org/articles/17600

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