Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor

Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor

Overexpression of ATP-binding cassette transporter superfamily G member 2 (ABCG2), is known as a major mechanism mediating multidrug resistance (MDR) in cancer cells. MLN7243 is a small-molecule ubiquitin activating enzyme inhibitor currently under clinical investigation. The aim of the current stud...

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Bibliographic Details
Main Authors: Zhuo-Xun Wu, Yuqi Yang, Jing-Quan Wang, Silpa Narayanan, Zi-Ning Lei, Qiu-Xu Teng, Leli Zeng, Zhe-Sheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
multidrug resistance
MLN7243
transported substrate
ATP-binding cassette transporters
ABCG2
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.697927/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.697927/full

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