“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin
Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as “head-to-side-chain” cyclodepsipeptides, have been isolated and characterized. These peptides present a unique structural arrangement that comprises a macrocyclic region closed through an ester bond b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-05-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/11/5/1693 |
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doaj-a631b2fafa7a461793fa81263d60fe792020-11-24T20:55:56ZengMDPI AGMarine Drugs1660-33972013-05-011151693171710.3390/md11051693“Head-to-Side-Chain” Cyclodepsipeptides of Marine OriginMarta Pelay-GimenoFernando AlbericioJudit Tulla-PucheSince the late 1980s, a large number of depsipeptides that contain a new topography, referred to as “head-to-side-chain” cyclodepsipeptides, have been isolated and characterized. These peptides present a unique structural arrangement that comprises a macrocyclic region closed through an ester bond between the C-terminus and a β-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. This structural pattern, the presence of unique and complex residues, and relevant bioactivity are the main features shared by all the members of this new class of depsipeptides, which are reviewed herein.http://www.mdpi.com/1660-3397/11/5/1693natural productspeptidespolyketidestherapeutic agents |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Marta Pelay-Gimeno Fernando Albericio Judit Tulla-Puche |
| spellingShingle |
Marta Pelay-Gimeno Fernando Albericio Judit Tulla-Puche “Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin Marine Drugs natural products peptides polyketides therapeutic agents |
| author_facet |
Marta Pelay-Gimeno Fernando Albericio Judit Tulla-Puche |
| author_sort |
Marta Pelay-Gimeno |
| title |
“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin |
| title_short |
“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin |
| title_full |
“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin |
| title_fullStr |
“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin |
| title_full_unstemmed |
“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin |
| title_sort |
“head-to-side-chain” cyclodepsipeptides of marine origin |
| publisher |
MDPI AG |
| series |
Marine Drugs |
| issn |
1660-3397 |
| publishDate |
2013-05-01 |
| description |
Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as “head-to-side-chain” cyclodepsipeptides, have been isolated and characterized. These peptides present a unique structural arrangement that comprises a macrocyclic region closed through an ester bond between the C-terminus and a β-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. This structural pattern, the presence of unique and complex residues, and relevant bioactivity are the main features shared by all the members of this new class of depsipeptides, which are reviewed herein. |
| topic |
natural products peptides polyketides therapeutic agents |
| url |
http://www.mdpi.com/1660-3397/11/5/1693 |
| work_keys_str_mv |
AT martapelaygimeno headtosidechaincyclodepsipeptidesofmarineorigin AT fernandoalbericio headtosidechaincyclodepsipeptidesofmarineorigin AT judittullapuche headtosidechaincyclodepsipeptidesofmarineorigin |
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1716791439029960704 |