Dysregulation of PI3K-Akt-mTOR pathway in brain of streptozotocin-induced type 2 diabetes mellitus in Wistar rats

Dysregulation of PI3K-Akt-mTOR pathway in brain of streptozotocin-induced type 2 diabetes mellitus in Wistar rats

Abstract Background Proteins of the insulin signaling pathway are needed for cell proliferation and development and glucose homeostasis. It is not known whether insulin signalling markers (Foxo1, Gsk3β) can be correlated with the expression on PI3K-Akt-mTOR pathway, which are needed for cell surviva...

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Bibliographic Details
Main Authors: Siresha Bathina, Undurti N. Das
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Lipids in Health and Disease
Subjects:
Streptozotocin
PI3K
Insulin signaling
β-Cell survival
Online Access:http://link.springer.com/article/10.1186/s12944-018-0809-2

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