Consequences of hypoxia-reoxygenation phenomena in patients with obstructive sleep apnea syndrome
<b>Background and Objectives :</b> Obstructive sleep apnea syndrome (OSAS) is a common disorder characterized by numerous episodes of absence of respiratory flow during sleep, which can be followed by a decrease in SaO<sub>2</sub> , which is rapidly normalized when ventilatio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
King Faisal Specialist Hospital and Research Centre
2011-01-01
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| Series: | Annals of Saudi Medicine |
| Online Access: | http://www.saudiannals.net/article.asp?issn=0256-4947;year=2011;volume=31;issue=1;spage=14;epage=18;aulast=Ciftci |
| Summary: | <b>Background and Objectives :</b> Obstructive sleep apnea syndrome (OSAS) is a common disorder characterized by numerous episodes of absence of respiratory flow during sleep, which can be followed by a decrease in SaO<sub>2</sub> , which is rapidly normalized when ventilation resumes. We hypothesize that this hypoxia-reoxygenation phenomena may affect the generation of vascular endothelial growth factor (VEGF), erythropoietin (EPO), endothelin-1 (ENDO-1), and inducible nitric oxide synthase (iNOS). <b>Design and Setting :</b> Prospective, patients referred to sleep disorders center. <b>Patients and Methods :</b> The presence and severity of OSAS were determined using the standard overnight polysomnography. Diagnosis of OSAS was made when the apnea-hypopnea index (AHI) was ≥15, independent of the appearance of symptoms. Serum levels of VEGF, EPO, ENDO-1, and nitrite-nitrate were measured after overnight fasting in 69 patients with OSAS and in 17 healthy control subjects. Serum levels of VEGF and nitrite-nitrate were measured again after 12 weeks of treatment with continuous positive airway pressure (CPAP) in OSAS patients. <b>Results</b> : Serum VEGF levels were found to be significantly higher and nitrite-nitrate levels were found to be significantly lower in OSAS patients than in controls (<i>P</i>=.003, .008, respectively), but no differences in EPO and ENDO-1 levels were found between the groups. We demonstrated that in OSAS patients, the serum VEGF levels were decreased and nitrate levels were increased after 12 weeks of CPAP treatment (<i>P</i>=.001, .002, respectively). <b>Conclusion</b> : According to our data, it is likely that hypoxia-reoxygenation phenomena affect the VEGF and nitrite-nitrate levels, which may be pathogenic factors in generating cardiovascular complications in OSAS. |
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| ISSN: | 0256-4947 0975-4466 |