Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption

Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption

There is no guideline concerning choice of antiretroviral therapy (ART) for HIV-infected patients after unplanned interruption. We conducted a retrospective cohort study of HIV-infected patients reintroduced to first-line ART after having unplanned interruption for at least 1 month. Viral load was e...

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Main Authors: Suzy Maria MD, Evy Yunihastuti MD, PhD, Siti Rizny F. Saldi MSc, Zubairi Djoerban MD
Format: Article
Language:English
Published: SAGE Publishing 2020-01-01
Series:Journal of the International Association of Providers of AIDS Care
Online Access:https://doi.org/10.1177/2325958219899534
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spelling doaj-a6247b4a483b4e689f7b9a81043537de2020-11-25T03:20:16ZengSAGE PublishingJournal of the International Association of Providers of AIDS Care2325-95822020-01-011910.1177/2325958219899534Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned InterruptionSuzy Maria MD0Evy Yunihastuti MD, PhD1Siti Rizny F. Saldi MSc2Zubairi Djoerban MD3 HIV Integrated Service, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia HIV Integrated Service, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia Center for Clinical Epidemiology and Evidence Based Medicine (CEEBM), Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia HIV Integrated Service, Dr. Cipto Mangunkusumo General Hospital, Jakarta, IndonesiaThere is no guideline concerning choice of antiretroviral therapy (ART) for HIV-infected patients after unplanned interruption. We conducted a retrospective cohort study of HIV-infected patients reintroduced to first-line ART after having unplanned interruption for at least 1 month. Viral load was evaluated at 6 to 18 months after the reintroduction. There were 100 patients included in our study, and 55 of them achieved virological success. History of single interruption (adjusted odds ratio [aOR] 5.51%, 95% confidence interval [CI] 1.82-16.68, P = .003) and CD4 count ≥200 cell/mm 3 at the time of reintroduction (aOR 4.33, 95% CI 1.14-16.39, P = .031) increased likelihood to achieve virological success.https://doi.org/10.1177/2325958219899534
collection DOAJ
language English
format Article
sources DOAJ
author Suzy Maria MD
Evy Yunihastuti MD, PhD
Siti Rizny F. Saldi MSc
Zubairi Djoerban MD
spellingShingle Suzy Maria MD
Evy Yunihastuti MD, PhD
Siti Rizny F. Saldi MSc
Zubairi Djoerban MD
Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption
Journal of the International Association of Providers of AIDS Care
author_facet Suzy Maria MD
Evy Yunihastuti MD, PhD
Siti Rizny F. Saldi MSc
Zubairi Djoerban MD
author_sort Suzy Maria MD
title Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption
title_short Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption
title_full Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption
title_fullStr Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption
title_full_unstemmed Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption
title_sort factors affecting virological outcome when first-line antiretroviral therapy is reintroduced after unplanned interruption
publisher SAGE Publishing
series Journal of the International Association of Providers of AIDS Care
issn 2325-9582
publishDate 2020-01-01
description There is no guideline concerning choice of antiretroviral therapy (ART) for HIV-infected patients after unplanned interruption. We conducted a retrospective cohort study of HIV-infected patients reintroduced to first-line ART after having unplanned interruption for at least 1 month. Viral load was evaluated at 6 to 18 months after the reintroduction. There were 100 patients included in our study, and 55 of them achieved virological success. History of single interruption (adjusted odds ratio [aOR] 5.51%, 95% confidence interval [CI] 1.82-16.68, P = .003) and CD4 count ≥200 cell/mm 3 at the time of reintroduction (aOR 4.33, 95% CI 1.14-16.39, P = .031) increased likelihood to achieve virological success.
url https://doi.org/10.1177/2325958219899534
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