Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells

Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells

Mitophagy is an evolutionarily conserved process that selectively targets impaired mitochondria for degradation. Defects in mitophagy are often associated with diverse pathologies, including cancer. Because the main known regulators of mitophagy are frequently inactivated in cancer cells, the mechan...

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Bibliographic Details
Main Authors: Elodie Villa, Emma Proïcs, Camila Rubio-Patiño, Sandrine Obba, Barbara Zunino, Jozef P. Bossowski, Romain M. Rozier, Johanna Chiche, Laura Mondragón, Joel S. Riley, Sandrine Marchetti, Els Verhoeyen, Stephen W.G. Tait, Jean-Ehrland Ricci
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
mitophagy
ARIH1
RBR-ligase
cell death
E3 ligase
Parkin-independent
chemoresistance
PINK1
lung cancer
mtKeima
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312299

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