Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice

Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice

Lentils (Lens culinaris L.) are a protein-rich plant food, also enriched in fibre and phenolic compounds that may reduce intestinal-associated disease risk. Male C57Bl/6 mice were pre-fed a basal diet (BD) or isocaloric 20% red lentil-supplemented diet (LD) for 3 weeks and acute colitis was induced...

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Main Authors: Daniela Graf, Jennifer M. Monk, Wenqing Wu, Hannah R. Wellings, Lindsay E. Robinson, Krista A. Power
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Functional Foods
Subjects:
Lentils
Pulses
Colitis
Inflammation
Cytokines
Dextran sodium sulfate
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464619305493
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spelling doaj-a6223467861f4a1cad7b9a665de6685c2021-04-30T07:17:38ZengElsevierJournal of Functional Foods1756-46462020-01-0164103625Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male miceDaniela Graf0Jennifer M. Monk1Wenqing Wu2Hannah R. Wellings3Lindsay E. Robinson4Krista A. Power5Guelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada; Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institute, Karlsruhe, GermanyGuelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, CanadaGuelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, CanadaDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, CanadaGuelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada; School of Nutrition Sciences, University of Ottawa, Ottawa, ON K1H 8L1, Canada; Corresponding author at: School of Nutrition Sciences, University of Ottawa, Roger Guindon Hall, Room 3260, Canada.Lentils (Lens culinaris L.) are a protein-rich plant food, also enriched in fibre and phenolic compounds that may reduce intestinal-associated disease risk. Male C57Bl/6 mice were pre-fed a basal diet (BD) or isocaloric 20% red lentil-supplemented diet (LD) for 3 weeks and acute colitis was induced via dextran sodium sulfate (DSS, 2% w/v in drinking water) for 5 days. LD-fed mice exhibited reduced (i) clinical symptoms, (ii) colon histological damage, and (iii) colonic pro-inflammatory cytokine levels. Additionally, biomarkers of improved colon epithelial barrier integrity and mucosal repair mediators were increased in LD mice (e.g. colonic IL-22, Relmβ, and occludin expression, and serum lipopolysaccharide binding protein). Collectively, the severity of the DSS-induced acute colitis phenotype in mice was attenuated by red lentil dietary supplementation, indicating that lentils may serve as a potential adjuvant dietary therapy in patients with colitis-associated diseases to help limit colonic inflammation and restore barrier function.http://www.sciencedirect.com/science/article/pii/S1756464619305493LentilsPulsesColitisInflammationCytokinesDextran sodium sulfate
collection DOAJ
language English
format Article
sources DOAJ
author Daniela Graf
Jennifer M. Monk
Wenqing Wu
Hannah R. Wellings
Lindsay E. Robinson
Krista A. Power
spellingShingle Daniela Graf
Jennifer M. Monk
Wenqing Wu
Hannah R. Wellings
Lindsay E. Robinson
Krista A. Power
Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice
Journal of Functional Foods
Lentils
Pulses
Colitis
Inflammation
Cytokines
Dextran sodium sulfate
author_facet Daniela Graf
Jennifer M. Monk
Wenqing Wu
Hannah R. Wellings
Lindsay E. Robinson
Krista A. Power
author_sort Daniela Graf
title Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice
title_short Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice
title_full Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice
title_fullStr Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice
title_full_unstemmed Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice
title_sort red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in c57bl/6 male mice
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2020-01-01
description Lentils (Lens culinaris L.) are a protein-rich plant food, also enriched in fibre and phenolic compounds that may reduce intestinal-associated disease risk. Male C57Bl/6 mice were pre-fed a basal diet (BD) or isocaloric 20% red lentil-supplemented diet (LD) for 3 weeks and acute colitis was induced via dextran sodium sulfate (DSS, 2% w/v in drinking water) for 5 days. LD-fed mice exhibited reduced (i) clinical symptoms, (ii) colon histological damage, and (iii) colonic pro-inflammatory cytokine levels. Additionally, biomarkers of improved colon epithelial barrier integrity and mucosal repair mediators were increased in LD mice (e.g. colonic IL-22, Relmβ, and occludin expression, and serum lipopolysaccharide binding protein). Collectively, the severity of the DSS-induced acute colitis phenotype in mice was attenuated by red lentil dietary supplementation, indicating that lentils may serve as a potential adjuvant dietary therapy in patients with colitis-associated diseases to help limit colonic inflammation and restore barrier function.
topic Lentils
Pulses
Colitis
Inflammation
Cytokines
Dextran sodium sulfate
url http://www.sciencedirect.com/science/article/pii/S1756464619305493
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