Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets.

Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets.

Runt-related transcription factor 1 (Runx1) can act as both an activator and a repressor. Here we show that CRISPR-mediated deletion of Runx1 in mouse metanephric mesenchyme-derived mK4 cells results in large-scale genome-wide changes to chromatin accessibility and gene expression. Open chromatin re...

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Bibliographic Details
Main Authors: Matthew R Hass, Daniel Brissette, Sreeja Parameswaran, Mario Pujato, Omer Donmez, Leah C Kottyan, Matthew T Weirauch, Raphael Kopan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009574

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