Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions
Protein-based biosensors have been engineered to interrogate cellular signaling and manipulate function. Here the authors demonstrate iSNAP, a tool to detect tyrosine phosphorylation and activate desired protein enzymes allowing the control of phagocytosis in macrophages.
Bibliographic Details
| Main Authors: |
Jie Sun,
Lei Lei,
Chih-Ming Tsai,
Yi Wang,
Yiwen Shi,
Mingxing Ouyang,
Shaoying Lu,
Jihye Seong,
Tae-Jin Kim,
Pengzhi Wang,
Min Huang,
Xiangdong Xu,
Victor Nizet,
Shu Chien,
Yingxiao Wang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-00569-6
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