Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC

Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC

Escherichia coli is a common cause of mastitis in dairy cows. The adaptor protein apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) synergizes with caspase-1 to regulate inflammasome activation during pathogen infection. Here, the ASC gene was knocked out in bovin...

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Bibliographic Details
Main Authors: Qiong Wu, Yao-Hong Zhu, Jin Xu, Xiao Liu, Cong Duan, Mei-Jun Wang, Jiu-Feng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
bovine mammary epithelial cell
Lactobacillus rhamnosus
Escherichia coli
inflammasome
ASC
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01661/full

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