Oxidative stress and its involvement in the development and course of urinary system diseases in children

• Main Author: E. M. Pleshkova
• Format: Article
• Language: Russian
• Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2016-03-01
• Series: Rossijskij Vestnik Perinatologii i Pediatrii
• Subjects: children; oxidative stress; reactive oxygen species; apoptosis; nephrosclerosis; urinary system diseases.
• Online Access: https://www.ped-perinatology.ru/jour/article/view/229

The paper presents data on free radical oxidation as a universal physiological process in the cell. In health, at the low concentrations of reactive oxygen species under the control of the antioxidant system, these are involved in the regulation of vascular tone and immune defense and act as second messengers to transmit signals across the cell membrane. Urinary system diseases develop oxidative stress. The reactive oxygen species are shown to be involved in the regulation of extracellular matrix metabolism, apoptosis, by contributing to the development of nephrosclerosis and the progression of chronic kidney disease. Many aspects of free radical reactions in urinary system diseases in children require that they should be investigated using current direct control methods. There is a need for further development of new approaches to combination treatment using antioxidant agents in children with for urinary system diseases.