Solubility of atenolol in ethanol+ water mixtures at various temperatures
The experimental solubility of atenolol in ethanol + water mixtures at different temperatures (298.2, 303.2, 308.2 and 313.2 K) was reported. The solubility was calculated with five numerical methods; i.e., the Jouyban-Acree model (method I), its combination with van’t Hoff equation (met...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Serbian Chemical Society
2015-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2015/0352-51391400095H.pdf |
| Summary: | The experimental solubility of atenolol in ethanol + water mixtures at
different temperatures (298.2, 303.2, 308.2 and 313.2 K) was reported. The
solubility was calculated with five numerical methods; i.e., the
Jouyban-Acree model (method I), its combination with van’t Hoff equation
(method II), the extended version of the Jouyban-Acree model with Abraham
parameters (method III), the minimum number of data points (N) were used to
train the Jouyban-Acree model (N=11) and its combination with van’t Hoff
equation (N=22), then obtained parameters of the models were used to
calculate the solubilites at other temperatures (methods IV and V). The
accuracies of the calculated solubilites were evaluated by computing mean
percentage deviation (MPD). The obtained MPDs (± standard deviation) for
methods I, II, III, IV and V were 5.6±7.1, 5.1±4.6, 34.1±28.0, 10.0±9.6 and
6.6±4.8%, respectively. |
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| ISSN: | 0352-5139 1820-7421 |