Research advances in the mechanism of fructose-induced nonalcoholic fatty liver disease

• Main Author: CHEN Ye
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2017-12-01
• Series: Linchuang Gandanbing Zazhi
• Subjects: nonalcoholic fatty liver disease； fructose； review
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=8645

In recent years, the incidence rate of nonalcoholic fatty liver disease (NAFLD) tends to increase in both developed and developing countries, which is associated with an increase in fructose consumption. This article points out that chronic persistent fructose intake can significantly promote de novo lipogenesis (DNL) in the liver and induce ATP depletion and inhibition of hepatocyte regeneration, which further causes endoplasmic reticulum stress and increased production of reactive oxygen species in the liver and finally leads to the development of NAFLD. It is believed that detailed mechanism of fructose-induced NAFLD and disruption of fructose metabolism in the liver may provide new therapeutic strategies for NAFLD.