Ischemic Mitral Regurgitation: A Multifaceted Syndrome with Evolving Therapies

Ischemic Mitral Regurgitation: A Multifaceted Syndrome with Evolving Therapies

Dysfunction of the left ventricle (LV) with impaired contractility following chronic ischemia or acute myocardial infarction (AMI) is the main cause of ischemic mitral regurgitation (IMR), leading to moderate and moderate-to-severe mitral regurgitation (MR). The site of AMI exerts a specific influen...

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Main Authors: Mattia Vinciguerra, Francesco Grigioni, Silvia Romiti, Giovanni Benfari, David Rose, Cristiano Spadaccio, Sara Cimino, Antonio De Bellis, Ernesto Greco
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomedicines
Subjects:
ischemic mitral regurgitation
symmetric tethering
asymmetric tethering
mitral valve repair
Mitra-Clip
Online Access:https://www.mdpi.com/2227-9059/9/5/447
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spelling doaj-a6038c4314614e9cbaea160c1e3732192021-04-21T23:05:15ZengMDPI AGBiomedicines2227-90592021-04-01944744710.3390/biomedicines9050447Ischemic Mitral Regurgitation: A Multifaceted Syndrome with Evolving TherapiesMattia Vinciguerra0Francesco Grigioni1Silvia Romiti2Giovanni Benfari3David Rose4Cristiano Spadaccio5Sara Cimino6Antonio De Bellis7Ernesto Greco8Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyUnit of Cardiovascular Sciences, Department of Medicine Campus Bio-Medico, University of Rome, 00128 Rome, ItalyDepartment of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyDivision of Cardiology, Department of Medicine, University of Verona, 37219 Verona, ItalyLancashire Cardiac Centre, Blackpool Victoria Hospital, Blackpool FY3 8NP, UKLancashire Cardiac Centre, Blackpool Victoria Hospital, Blackpool FY3 8NP, UKDepartment of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Cardiology and Cardiac Surgery, Casa di Cura “S. Michele”, 81024 Maddaloni, Caserta, ItalyDepartment of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyDysfunction of the left ventricle (LV) with impaired contractility following chronic ischemia or acute myocardial infarction (AMI) is the main cause of ischemic mitral regurgitation (IMR), leading to moderate and moderate-to-severe mitral regurgitation (MR). The site of AMI exerts a specific influence determining different patterns of adverse LV remodeling. In general, inferior-posterior AMI is more frequently associated with regional structural changes than the anterolateral one, which is associated with global adverse LV remodeling, ultimately leading to different phenotypes of IMR. In this narrative review, starting from the aforementioned categorization, we proceed to describe current knowledge regarding surgical approaches in the management of IMR.https://www.mdpi.com/2227-9059/9/5/447ischemic mitral regurgitationsymmetric tetheringasymmetric tetheringmitral valve repairMitra-Clip
collection DOAJ
language English
format Article
sources DOAJ
author Mattia Vinciguerra
Francesco Grigioni
Silvia Romiti
Giovanni Benfari
David Rose
Cristiano Spadaccio
Sara Cimino
Antonio De Bellis
Ernesto Greco
spellingShingle Mattia Vinciguerra
Francesco Grigioni
Silvia Romiti
Giovanni Benfari
David Rose
Cristiano Spadaccio
Sara Cimino
Antonio De Bellis
Ernesto Greco
Ischemic Mitral Regurgitation: A Multifaceted Syndrome with Evolving Therapies
Biomedicines
ischemic mitral regurgitation
symmetric tethering
asymmetric tethering
mitral valve repair
Mitra-Clip
author_facet Mattia Vinciguerra
Francesco Grigioni
Silvia Romiti
Giovanni Benfari
David Rose
Cristiano Spadaccio
Sara Cimino
Antonio De Bellis
Ernesto Greco
author_sort Mattia Vinciguerra
title Ischemic Mitral Regurgitation: A Multifaceted Syndrome with Evolving Therapies
title_short Ischemic Mitral Regurgitation: A Multifaceted Syndrome with Evolving Therapies
title_full Ischemic Mitral Regurgitation: A Multifaceted Syndrome with Evolving Therapies
title_fullStr Ischemic Mitral Regurgitation: A Multifaceted Syndrome with Evolving Therapies
title_full_unstemmed Ischemic Mitral Regurgitation: A Multifaceted Syndrome with Evolving Therapies
title_sort ischemic mitral regurgitation: a multifaceted syndrome with evolving therapies
publisher MDPI AG
series Biomedicines
issn 2227-9059
publishDate 2021-04-01
description Dysfunction of the left ventricle (LV) with impaired contractility following chronic ischemia or acute myocardial infarction (AMI) is the main cause of ischemic mitral regurgitation (IMR), leading to moderate and moderate-to-severe mitral regurgitation (MR). The site of AMI exerts a specific influence determining different patterns of adverse LV remodeling. In general, inferior-posterior AMI is more frequently associated with regional structural changes than the anterolateral one, which is associated with global adverse LV remodeling, ultimately leading to different phenotypes of IMR. In this narrative review, starting from the aforementioned categorization, we proceed to describe current knowledge regarding surgical approaches in the management of IMR.
topic ischemic mitral regurgitation
symmetric tethering
asymmetric tethering
mitral valve repair
Mitra-Clip
url https://www.mdpi.com/2227-9059/9/5/447
work_keys_str_mv AT mattiavinciguerra ischemicmitralregurgitationamultifacetedsyndromewithevolvingtherapies
AT francescogrigioni ischemicmitralregurgitationamultifacetedsyndromewithevolvingtherapies
AT silviaromiti ischemicmitralregurgitationamultifacetedsyndromewithevolvingtherapies
AT giovannibenfari ischemicmitralregurgitationamultifacetedsyndromewithevolvingtherapies
AT davidrose ischemicmitralregurgitationamultifacetedsyndromewithevolvingtherapies
AT cristianospadaccio ischemicmitralregurgitationamultifacetedsyndromewithevolvingtherapies
AT saracimino ischemicmitralregurgitationamultifacetedsyndromewithevolvingtherapies
AT antoniodebellis ischemicmitralregurgitationamultifacetedsyndromewithevolvingtherapies
AT ernestogreco ischemicmitralregurgitationamultifacetedsyndromewithevolvingtherapies
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