High prevalence of occult thrombosis in cases of mild/moderate COVID-19

• Main Authors: Budong Chen, Chunguo Jiang, Bing Han, Chunshuang Guan, Gaoli Fang, Shuo Yan, Kexin Wang, Ligai Liu, Christopher P. Conlon, Ruming Xie, Rui Song
• Format: Article
• Language: English
• Published: Elsevier 2021-03-01
• Series: International Journal of Infectious Diseases
• Subjects: COVID-19; Venous thromboembolism; Thrombotic complications; Mild/moderate COVID-19
• Online Access: http://www.sciencedirect.com/science/article/pii/S1201971220325662

Background and purpose: An increasing number of reports have observed thrombosis in severe cases of COVID-19. The aim of this study was to evaluate the incidence of thromboembolism in mild/moderate cases of COVID-19. All of the patients had normal coagulation tests and none had any overt thrombotic complications. Our findings indicate that it is important to screen the thrombotic status of cases with mild/moderate COVID-19. Methods: Between 11 June and 8 July 2020, 23 patients with mild/moderate COVID-19 pneumonia consented to having computed tomography pulmonary angiography (CPTA) and computed tomography venography (CTV) scans of the lungs and extremity veins. Doppler ultrasound (DUS) was also performed in all patients for screening. The incidence, clinical manifestations, laboratory examinations, imaging features, and prognosis, of patients with venous thromboembolism (VTE) were analyzed and compared with those of patients with COVID-19 pneumonia without VTE. Results: Nineteen patients (82.6%) had VTE, mainly distal limb thrombosis. Only one of the VTE patients was positive when screened by DUS; the other VTE patients were negative by DUS. All of the mild/moderate patients with VTE were screened by CTPA + CTV. Blood tests for inflammatory, coagulation, and biochemical, parameters were all within the normal range, except for WBC and LDH. Conclusions: When using CTV screening for DVT, we found that the incidence of thrombosis in patients with mild/moderate COVID-19 markedly increased to 82.6% (19/23). Screening for thrombosis is therefore important in patients with COVID-19. CTV is more sensitive than DUS for the detection of thrombosis. More research is now needed to evaluate the significance of thrombosis in COVID-19 pneumonia.