Soluble CD40L is associated with increased oxidative burst and neutrophil extracellular trap release in Behçet’s disease

Soluble CD40L is associated with increased oxidative burst and neutrophil extracellular trap release in Behçet’s disease

Abstract Background Studies have suggested that soluble factors in plasma from patients with active (aBD) and inactive (iBD) Behçet’s disease (BD) stimulate neutrophil function. Soluble CD40 ligand (sCD40L) is an important mediator of inflammation in BD. Its expression and effect on neutrophil oxida...

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Bibliographic Details
Main Authors: Sandro Félix Perazzio, Paulo Vitor Soeiro-Pereira, Viviane Cardoso dos Santos, Marlon Vilela de Brito, Bruno Salu, Maria Luiza Vilela Oliva, Anne Margherite Stevens, Alexandre Wagner Silva de Souza, Hans D. Ochs, Troy R. Torgerson, Antonio Condino-Neto, Luis Eduardo Coelho Andrade
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Arthritis Research & Therapy
Subjects:
Behçet’s disease
Neutrophil activation
sCD40L
CD40L pathway
Oxidative burst
Neutrophil extracellular traps
Online Access:http://link.springer.com/article/10.1186/s13075-017-1443-5

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http://link.springer.com/article/10.1186/s13075-017-1443-5

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