| Summary: | Stereotactic Ablative Body Radiotherapy (SABR) is a newer method of ultra hypo fractionated radiotherapy that uses combination of image guided radiotherapy (IGRT) and intensity modulated radiotherapy(IMRT) or volumetric modulated arc therapy(VMAT), to deliver high doses of radiation in a few fractions to a target, at the same time sparing the surrounding organs at risk(OAR).SABR is ideal for treating small volumes of disease and has been introduced in a number of disease sites including brain, lung, liver, spine and prostate. Given the radiobiological advantages of treating prostate cancer with high doses per fraction, SABR is becoming a standard of care for low and intermediate risk prostate cancer patients based upon the results from Sunny Brook and also the US-based prostate SABR consortium. This review examines the development of moderate and ultra hypo fractionation schedules at the Odette Cancer centre, Sunnybrook Health Sciences. Moderate hypo fractionation protocol was first developed in 2001 for intermediate risk prostate cancer and from there on different treatment schedules including SABR evolved for all risk groups.
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