A Cell Line for Detection of Botulinum Neurotoxin Type B

A Cell Line for Detection of Botulinum Neurotoxin Type B

Botulinum neurotoxins (BoNTs) type A and type B are commonly used as biopharmaceutics for neurological diseases, uniquely allowing months-long paralysis of target muscles. Their exquisite neuronal specificity is conferred by a multistep process of binding, internalization, cytosolic escape and cleav...

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Bibliographic Details
Main Authors:	Aleksander Rust, Ciara Doran, Rosalyn Hart, Thomas Binz, Paul Stickings, Dorothea Sesardic, Andrew A. Peden, Bazbek Davletov
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-11-01
Series:	Frontiers in Pharmacology
Subjects:	botulinum neurotoxin type B botulinum neurotoxin-sensitive cell line SiMa neuroblastoma VAMP tetanus luciferase
Online Access:	http://journal.frontiersin.org/article/10.3389/fphar.2017.00796/full

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