Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment.

Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment.

The Vpu accessory protein promotes HIV-1 release by counteracting Tetherin/BST-2, an interferon-regulated restriction factor, which retains virions at the cell-surface. Recent reports proposed beta-TrCP-dependent proteasomal and/or endo-lysosomal degradation of Tetherin as potential mechanisms by wh...

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Bibliographic Details
Main Authors: Mathieu Dubé, Bibhuti Bhusan Roy, Pierre Guiot-Guillain, Julie Binette, Johanne Mercier, Antoine Chiasson, Eric A Cohen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2851737?pdf=render

Internet

http://europepmc.org/articles/PMC2851737?pdf=render

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