Hazard and risk assessment of human exposure to toxic metals using in vitro digestion assay

• Main Authors: Hani A. Alhadrami, Lenka Mbadugha, Graeme I. Paton
• Format: Article
• Language: English
• Published: Taylor & Francis Group 2016-10-01
• Series: Chemical Speciation & Bioavailability
• Subjects: Oral bioavailability; human exposure; in vitro digestion assay; hazard and risk assessment; copper and nickel; TDI
• Online Access: http://dx.doi.org/10.1080/09542299.2016.1180961

Clean-up targets for toxic metals require that the site be “fit for purpose”. This means that targets are set with respect to defined receptors that reflect intended land-use. In this study, the likely threat of human exposure to toxic metals has been evaluated by simulating the human digestion process in vitro. The effects of key attributes (i.e. sample fraction size, pH, Kd and total metal concentrations) on the bioavailability of Cu and Ni were also investigated. Total metal concentration was the key explanatory factor for Cu and Ni bioavailability. A comparative ranking of metal concentrations in the context of tolerable daily intakes for Cu and Ni confirmed that the pH has the greatest impact on metals bioavailability. Rapid screening of key attributes and total toxic metal doses can reveal the relative hazard imposed on human, and this approach should be considered when defining threshold values for human protection.