The burden of non-communicable disease in transition communities in an Asian megacity: baseline findings from a cohort study in Karachi, Pakistan.

The demographic transition in South Asia coupled with unplanned urbanization and lifestyle changes are increasing the burden of non-communicable disease (NCD) where infectious diseases are still highly prevalent. The true magnitude and impact of this double burden of disease, although predicted to b...

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Main Authors: Faisal S Khan, Ismat Lotia-Farrukh, Aamir J Khan, Saad Tariq Siddiqui, Sana Zehra Sajun, Amyn Abdul Malik, Aziza Burfat, Mohammad Hussham Arshad, Andrew J Codlin, Belinda M Reininger, Joseph B McCormick, Nadeem Afridi, Susan P Fisher-Hoch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3572147?pdf=render
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spelling doaj-a5ca7470cf1342faaaac666f2ec291872020-11-25T01:52:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5600810.1371/journal.pone.0056008The burden of non-communicable disease in transition communities in an Asian megacity: baseline findings from a cohort study in Karachi, Pakistan.Faisal S KhanIsmat Lotia-FarrukhAamir J KhanSaad Tariq SiddiquiSana Zehra SajunAmyn Abdul MalikAziza BurfatMohammad Hussham ArshadAndrew J CodlinBelinda M ReiningerJoseph B McCormickNadeem AfridiSusan P Fisher-HochThe demographic transition in South Asia coupled with unplanned urbanization and lifestyle changes are increasing the burden of non-communicable disease (NCD) where infectious diseases are still highly prevalent. The true magnitude and impact of this double burden of disease, although predicted to be immense, is largely unknown due to the absence of recent, population-based longitudinal data. The present study was designed as a unique 'Framingham-like' Pakistan cohort with the objective of measuring the prevalence and risk factors for hypertension, obesity, diabetes, coronary artery disease and hepatitis B and C infection in a multi-ethnic, middle to low income population of Karachi, Pakistan.We selected two administrative areas from a private charitable hospital's catchment population for enrolment of a random selection of cohort households in Karachi, Pakistan. A baseline survey measured the prevalence and risk factors for hypertension, obesity, diabetes, coronary artery disease and hepatitis B and C infection.Six hundred and sixty-seven households were enrolled between March 2010 and August 2011. A majority of households lived in permanent structures (85%) with access to basic utilities (77%) and sanitation facilities (98%) but limited access to clean drinking water (68%). Households had high ownership of communication technologies in the form of cable television (69%) and mobile phones (83%). Risk factors for NCD, such as tobacco use (45%), overweight (20%), abdominal obesity (53%), hypertension (18%), diabetes (8%) and pre-diabetes (40%) were high. At the same time, infectious diseases such as hepatitis B (24%) and hepatitis C (8%) were prevalent in this population.Our findings highlight the need to monitor risk factors and disease trends through longitudinal research in high-burden transition communities in the context of rapid urbanization and changing lifestyles. They also demonstrate the urgency of public health intervention programs tailored for these transition communities.http://europepmc.org/articles/PMC3572147?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Faisal S Khan
Ismat Lotia-Farrukh
Aamir J Khan
Saad Tariq Siddiqui
Sana Zehra Sajun
Amyn Abdul Malik
Aziza Burfat
Mohammad Hussham Arshad
Andrew J Codlin
Belinda M Reininger
Joseph B McCormick
Nadeem Afridi
Susan P Fisher-Hoch
spellingShingle Faisal S Khan
Ismat Lotia-Farrukh
Aamir J Khan
Saad Tariq Siddiqui
Sana Zehra Sajun
Amyn Abdul Malik
Aziza Burfat
Mohammad Hussham Arshad
Andrew J Codlin
Belinda M Reininger
Joseph B McCormick
Nadeem Afridi
Susan P Fisher-Hoch
The burden of non-communicable disease in transition communities in an Asian megacity: baseline findings from a cohort study in Karachi, Pakistan.
PLoS ONE
author_facet Faisal S Khan
Ismat Lotia-Farrukh
Aamir J Khan
Saad Tariq Siddiqui
Sana Zehra Sajun
Amyn Abdul Malik
Aziza Burfat
Mohammad Hussham Arshad
Andrew J Codlin
Belinda M Reininger
Joseph B McCormick
Nadeem Afridi
Susan P Fisher-Hoch
author_sort Faisal S Khan
title The burden of non-communicable disease in transition communities in an Asian megacity: baseline findings from a cohort study in Karachi, Pakistan.
title_short The burden of non-communicable disease in transition communities in an Asian megacity: baseline findings from a cohort study in Karachi, Pakistan.
title_full The burden of non-communicable disease in transition communities in an Asian megacity: baseline findings from a cohort study in Karachi, Pakistan.
title_fullStr The burden of non-communicable disease in transition communities in an Asian megacity: baseline findings from a cohort study in Karachi, Pakistan.
title_full_unstemmed The burden of non-communicable disease in transition communities in an Asian megacity: baseline findings from a cohort study in Karachi, Pakistan.
title_sort burden of non-communicable disease in transition communities in an asian megacity: baseline findings from a cohort study in karachi, pakistan.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2013-01-01
description The demographic transition in South Asia coupled with unplanned urbanization and lifestyle changes are increasing the burden of non-communicable disease (NCD) where infectious diseases are still highly prevalent. The true magnitude and impact of this double burden of disease, although predicted to be immense, is largely unknown due to the absence of recent, population-based longitudinal data. The present study was designed as a unique 'Framingham-like' Pakistan cohort with the objective of measuring the prevalence and risk factors for hypertension, obesity, diabetes, coronary artery disease and hepatitis B and C infection in a multi-ethnic, middle to low income population of Karachi, Pakistan.We selected two administrative areas from a private charitable hospital's catchment population for enrolment of a random selection of cohort households in Karachi, Pakistan. A baseline survey measured the prevalence and risk factors for hypertension, obesity, diabetes, coronary artery disease and hepatitis B and C infection.Six hundred and sixty-seven households were enrolled between March 2010 and August 2011. A majority of households lived in permanent structures (85%) with access to basic utilities (77%) and sanitation facilities (98%) but limited access to clean drinking water (68%). Households had high ownership of communication technologies in the form of cable television (69%) and mobile phones (83%). Risk factors for NCD, such as tobacco use (45%), overweight (20%), abdominal obesity (53%), hypertension (18%), diabetes (8%) and pre-diabetes (40%) were high. At the same time, infectious diseases such as hepatitis B (24%) and hepatitis C (8%) were prevalent in this population.Our findings highlight the need to monitor risk factors and disease trends through longitudinal research in high-burden transition communities in the context of rapid urbanization and changing lifestyles. They also demonstrate the urgency of public health intervention programs tailored for these transition communities.
url http://europepmc.org/articles/PMC3572147?pdf=render
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