Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histology

Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histology

A 63-year-old Caucasian woman underwent total hysterectomy with bilateral salpingo-oophorectomy due to abnormal uterine bleeding. Gross examination of the hysterectomy specimen revealed a large polypoid mass filling the endometrial cavity. Histological examination revealed a tumor with two unique mo...

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Main Authors: Sara Makhdoum, MD, M. Ruhul Quddus, MD, M. Phil (Path), Michele M. Lomme, MD, Katrine Hansen, MD, W. Dwayne Lawrence, MD, MSc (Path)
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Human Pathology: Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2214330018301330
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spelling doaj-a5c9ee612642476484bbc929bca73bb02020-11-24T22:05:39ZengElsevierHuman Pathology: Case Reports2214-33002019-03-01159294Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histologySara Makhdoum, MD0M. Ruhul Quddus, MD, M. Phil (Path)1Michele M. Lomme, MD2Katrine Hansen, MD3W. Dwayne Lawrence, MD, MSc (Path)4Department of Pathology, Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI 02905, USA; King Faisal Specialist Hospital and Research Center, Department of Pathology and Laboratory Medicine, Riyadh, Saudi ArabiaDepartment of Pathology, Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI 02905, USA; Corresponding author at: Department of Pathology, Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI 02905, USA.Department of Pathology, Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI 02905, USADepartment of Pathology, Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI 02905, USADepartment of Pathology, Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI 02905, USAA 63-year-old Caucasian woman underwent total hysterectomy with bilateral salpingo-oophorectomy due to abnormal uterine bleeding. Gross examination of the hysterectomy specimen revealed a large polypoid mass filling the endometrial cavity. Histological examination revealed a tumor with two unique morphologic patterns with no overlap or transition from one pattern to the other. The low-grade component consisted of FIGO grade 1 endometrioid adenocarcinoma with unusual “balloon-cell” change, while the high grade component was an undifferentiated carcinoma with neuroendocrine features. Both components exhibited MLH1 and MSH6 loss by immunohistochemistry. To our knowledge, the current case is only the 5th documented case of dedifferentiated endometrioid carcinoma with neuroendocrine features. Keywords: Endometrium, Dedifferentiated carcinoma, Neuroendocrine features, Balloon-cell change, Microsatellite instabilityhttp://www.sciencedirect.com/science/article/pii/S2214330018301330
collection DOAJ
language English
format Article
sources DOAJ
author Sara Makhdoum, MD
M. Ruhul Quddus, MD, M. Phil (Path)
Michele M. Lomme, MD
Katrine Hansen, MD
W. Dwayne Lawrence, MD, MSc (Path)
spellingShingle Sara Makhdoum, MD
M. Ruhul Quddus, MD, M. Phil (Path)
Michele M. Lomme, MD
Katrine Hansen, MD
W. Dwayne Lawrence, MD, MSc (Path)
Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histology
Human Pathology: Case Reports
author_facet Sara Makhdoum, MD
M. Ruhul Quddus, MD, M. Phil (Path)
Michele M. Lomme, MD
Katrine Hansen, MD
W. Dwayne Lawrence, MD, MSc (Path)
author_sort Sara Makhdoum, MD
title Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histology
title_short Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histology
title_full Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histology
title_fullStr Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histology
title_full_unstemmed Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histology
title_sort dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: report of a rare entity with an unusual histology
publisher Elsevier
series Human Pathology: Case Reports
issn 2214-3300
publishDate 2019-03-01
description A 63-year-old Caucasian woman underwent total hysterectomy with bilateral salpingo-oophorectomy due to abnormal uterine bleeding. Gross examination of the hysterectomy specimen revealed a large polypoid mass filling the endometrial cavity. Histological examination revealed a tumor with two unique morphologic patterns with no overlap or transition from one pattern to the other. The low-grade component consisted of FIGO grade 1 endometrioid adenocarcinoma with unusual “balloon-cell” change, while the high grade component was an undifferentiated carcinoma with neuroendocrine features. Both components exhibited MLH1 and MSH6 loss by immunohistochemistry. To our knowledge, the current case is only the 5th documented case of dedifferentiated endometrioid carcinoma with neuroendocrine features. Keywords: Endometrium, Dedifferentiated carcinoma, Neuroendocrine features, Balloon-cell change, Microsatellite instability
url http://www.sciencedirect.com/science/article/pii/S2214330018301330
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