Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery
Heart failure is the leading cause of death in the western world and as such, there is a great need for new therapies. Heart failure has a variable presentation in patients and a complex etiology; however, it is fundamentally a condition that affects the mechanics of cardiac contraction, preventing...
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2018-09-01
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doaj-a5c82d7558aa4450ad59d43a3c1b06ed2020-11-24T22:22:23ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2018-09-01510.3389/fcvm.2018.00120402914Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug DiscoveryMichael J. Greenberg0Neil J. Daily1Ann Wang2Michael K. Conway3Tetsuro Wakatsuki4Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, United StatesInvivoSciences Inc., Madison, WI, United StatesInvivoSciences Inc., Madison, WI, United StatesInvivoSciences Inc., Madison, WI, United StatesInvivoSciences Inc., Madison, WI, United StatesHeart failure is the leading cause of death in the western world and as such, there is a great need for new therapies. Heart failure has a variable presentation in patients and a complex etiology; however, it is fundamentally a condition that affects the mechanics of cardiac contraction, preventing the heart from generating sufficient cardiac output under normal operating pressures. One of the major issues hindering the development of new therapies has been difficulties in developing appropriate in vitro model systems of human heart failure that recapitulate the essential changes in cardiac mechanics seen in the disease. Recent advances in stem cell technologies, genetic engineering, and tissue engineering have the potential to revolutionize our ability to model and study heart failure in vitro. Here, we review how these technologies are being applied to develop personalized models of heart failure and discover novel therapeutics.https://www.frontiersin.org/article/10.3389/fcvm.2018.00120/fullheart failuretissue engineeringlength-tension relationshipgene editinghuman induced pluripotent stem cellshigh-throughput screening |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michael J. Greenberg Neil J. Daily Ann Wang Michael K. Conway Tetsuro Wakatsuki |
spellingShingle |
Michael J. Greenberg Neil J. Daily Ann Wang Michael K. Conway Tetsuro Wakatsuki Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery Frontiers in Cardiovascular Medicine heart failure tissue engineering length-tension relationship gene editing human induced pluripotent stem cells high-throughput screening |
author_facet |
Michael J. Greenberg Neil J. Daily Ann Wang Michael K. Conway Tetsuro Wakatsuki |
author_sort |
Michael J. Greenberg |
title |
Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery |
title_short |
Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery |
title_full |
Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery |
title_fullStr |
Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery |
title_full_unstemmed |
Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery |
title_sort |
genetic and tissue engineering approaches to modeling the mechanics of human heart failure for drug discovery |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cardiovascular Medicine |
issn |
2297-055X |
publishDate |
2018-09-01 |
description |
Heart failure is the leading cause of death in the western world and as such, there is a great need for new therapies. Heart failure has a variable presentation in patients and a complex etiology; however, it is fundamentally a condition that affects the mechanics of cardiac contraction, preventing the heart from generating sufficient cardiac output under normal operating pressures. One of the major issues hindering the development of new therapies has been difficulties in developing appropriate in vitro model systems of human heart failure that recapitulate the essential changes in cardiac mechanics seen in the disease. Recent advances in stem cell technologies, genetic engineering, and tissue engineering have the potential to revolutionize our ability to model and study heart failure in vitro. Here, we review how these technologies are being applied to develop personalized models of heart failure and discover novel therapeutics. |
topic |
heart failure tissue engineering length-tension relationship gene editing human induced pluripotent stem cells high-throughput screening |
url |
https://www.frontiersin.org/article/10.3389/fcvm.2018.00120/full |
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