Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery

Heart failure is the leading cause of death in the western world and as such, there is a great need for new therapies. Heart failure has a variable presentation in patients and a complex etiology; however, it is fundamentally a condition that affects the mechanics of cardiac contraction, preventing...

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Main Authors: Michael J. Greenberg, Neil J. Daily, Ann Wang, Michael K. Conway, Tetsuro Wakatsuki
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2018.00120/full
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spelling doaj-a5c82d7558aa4450ad59d43a3c1b06ed2020-11-24T22:22:23ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2018-09-01510.3389/fcvm.2018.00120402914Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug DiscoveryMichael J. Greenberg0Neil J. Daily1Ann Wang2Michael K. Conway3Tetsuro Wakatsuki4Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, United StatesInvivoSciences Inc., Madison, WI, United StatesInvivoSciences Inc., Madison, WI, United StatesInvivoSciences Inc., Madison, WI, United StatesInvivoSciences Inc., Madison, WI, United StatesHeart failure is the leading cause of death in the western world and as such, there is a great need for new therapies. Heart failure has a variable presentation in patients and a complex etiology; however, it is fundamentally a condition that affects the mechanics of cardiac contraction, preventing the heart from generating sufficient cardiac output under normal operating pressures. One of the major issues hindering the development of new therapies has been difficulties in developing appropriate in vitro model systems of human heart failure that recapitulate the essential changes in cardiac mechanics seen in the disease. Recent advances in stem cell technologies, genetic engineering, and tissue engineering have the potential to revolutionize our ability to model and study heart failure in vitro. Here, we review how these technologies are being applied to develop personalized models of heart failure and discover novel therapeutics.https://www.frontiersin.org/article/10.3389/fcvm.2018.00120/fullheart failuretissue engineeringlength-tension relationshipgene editinghuman induced pluripotent stem cellshigh-throughput screening
collection DOAJ
language English
format Article
sources DOAJ
author Michael J. Greenberg
Neil J. Daily
Ann Wang
Michael K. Conway
Tetsuro Wakatsuki
spellingShingle Michael J. Greenberg
Neil J. Daily
Ann Wang
Michael K. Conway
Tetsuro Wakatsuki
Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery
Frontiers in Cardiovascular Medicine
heart failure
tissue engineering
length-tension relationship
gene editing
human induced pluripotent stem cells
high-throughput screening
author_facet Michael J. Greenberg
Neil J. Daily
Ann Wang
Michael K. Conway
Tetsuro Wakatsuki
author_sort Michael J. Greenberg
title Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery
title_short Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery
title_full Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery
title_fullStr Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery
title_full_unstemmed Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery
title_sort genetic and tissue engineering approaches to modeling the mechanics of human heart failure for drug discovery
publisher Frontiers Media S.A.
series Frontiers in Cardiovascular Medicine
issn 2297-055X
publishDate 2018-09-01
description Heart failure is the leading cause of death in the western world and as such, there is a great need for new therapies. Heart failure has a variable presentation in patients and a complex etiology; however, it is fundamentally a condition that affects the mechanics of cardiac contraction, preventing the heart from generating sufficient cardiac output under normal operating pressures. One of the major issues hindering the development of new therapies has been difficulties in developing appropriate in vitro model systems of human heart failure that recapitulate the essential changes in cardiac mechanics seen in the disease. Recent advances in stem cell technologies, genetic engineering, and tissue engineering have the potential to revolutionize our ability to model and study heart failure in vitro. Here, we review how these technologies are being applied to develop personalized models of heart failure and discover novel therapeutics.
topic heart failure
tissue engineering
length-tension relationship
gene editing
human induced pluripotent stem cells
high-throughput screening
url https://www.frontiersin.org/article/10.3389/fcvm.2018.00120/full
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