Modeling the effect of intratumoral heterogeneity of radiosensitivity on tumor response over the course of fractionated radiation therapy

Modeling the effect of intratumoral heterogeneity of radiosensitivity on tumor response over the course of fractionated radiation therapy

Abstract Background Standard radiobiology theory of radiation response assumes a uniform innate radiosensitivity of tumors. However, experimental data show that there is significant intratumoral heterogeneity of radiosensitivity. Therefore, a model with heterogeneity was developed and tested using e...

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Bibliographic Details
Main Authors: J. C. L. Alfonso, L. Berk
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Radiation Oncology
Subjects:
Intratumoral radiosensitivity heterogeneity
Radiation resistance
Linear-quadratic model
Fractionated radiotherapy
Accelerated repopulation
Online Access:http://link.springer.com/article/10.1186/s13014-019-1288-y

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http://link.springer.com/article/10.1186/s13014-019-1288-y

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