Mechanistic Studies on Regioselective Dephosphorylation of Phosphate Prodrugs during a Facile Synthesis of Antitumor Phosphorylated 2-Phenyl-6,7-methylenedioxy-1H-quinolin-4-one

Mechanistic Studies on Regioselective Dephosphorylation of Phosphate Prodrugs during a Facile Synthesis of Antitumor Phosphorylated 2-Phenyl-6,7-methylenedioxy-1H-quinolin-4-one

Phosphorylation of 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxy-1H-quinolin-4-one (1) afforded diphosphate 2. We found that, upon treatment with methanol under mild conditions, 2 can undergo facile and highly regioselective dephosphorylation to give the monophosphate 3, with a phosphate group re...

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Bibliographic Details
Main Authors: Sheng-Chu Kuo, Cheng-Tung Lin, Chi-Hung Huang, Kuo-Hsiung Lee, Li-Jiau Huang, Yung-Yi Cheng, Chin-Yu Liu
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Molecules
Subjects:
MCF-7
prodrugs
dephosphorylation
antitumor activity
Online Access:http://www.mdpi.com/1420-3049/18/7/8028

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