Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging

Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging

We describe here the design and implementation of an in vitro microvascular open model system using human brain microvascular endothelial cells. The design has several advantages over other traditional closed microfluidic platforms: (1) it enables controlled unidirectional flow of media at physiolog...

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Bibliographic Details
Main Authors: Mootaz M. Salman, Graham Marsh, Ilja Kusters, Matthieu Delincé, Giuseppe Di Caprio, Srigokul Upadhyayula, Giovanni de Nola, Ronan Hunt, Kazuka G. Ohashi, Taylor Gray, Fumitaka Shimizu, Yasuteru Sano, Takashi Kanda, Birgit Obermeier, Tom Kirchhausen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
blood-brain barrier (BBB)
capillary
microvessel
shear stress
microfluidics
live cell imaging
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.573775/full

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