EMP3 mediates glioblastoma‐associated macrophage infiltration to drive T cell exclusion

EMP3 mediates glioblastoma‐associated macrophage infiltration to drive T cell exclusion

Abstract Background The immunosuppressive tumour microenvironment is a critical factor in the initiation and progression of glioblastoma (GBM), which is characterized by an abundance of tumour-associated macrophages (TAMs) but a paucity of infiltrating T cells. In this research, we studied whether e...

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Bibliographic Details
Main Authors:	Qun Chen, Jing Jin, Xin Huang, Fan Wu, Hongguang Huang, Renya Zhan
Format:	Article
Language:	English
Published:	BMC 2021-05-01
Series:	Journal of Experimental & Clinical Cancer Research
Subjects:	Glioblastoma Epithelial membrane protein 3 Exhausted T cells Tumour‐associated macrophages
Online Access:	https://doi.org/10.1186/s13046-021-01954-2

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