Prophylactic intervention of probiotics (L.acidophilus, L.rhamnosus GG) and celecoxib modulate Bax-mediated apoptosis in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis

Prophylactic intervention of probiotics (L.acidophilus, L.rhamnosus GG) and celecoxib modulate Bax-mediated apoptosis in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis

Abstract Background Colorectal cancer has been found to be attenuated either with prophylactic manipulation of gut microbiome with probiotics or celecoxib, a non-steroidal anti-inflammatory drug mainly by suppressing early pro-carcinogenic markers in various experimental studies. Therefore, the pres...

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Bibliographic Details
Main Authors: Leila Kaeid Sharaf, Mridul Sharma, Deepika Chandel, Geeta Shukla
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Cancer
Subjects:
Apoptosis
Colorectal cancer
Gastrointestinal diseases
Celecoxib
Probiotics
Online Access:http://link.springer.com/article/10.1186/s12885-018-4999-9

Internet

http://link.springer.com/article/10.1186/s12885-018-4999-9

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